Emerging New Concepts of Degrader Technologies.

Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This typically relies on a measurable biochemical readout and accessible binding sites whose occupancy influences the function of the target protein. These requirements preclude many disease-causing proteins from being ‘druggable’ targets, and these proteins are categorized as ‘undruggable’.

The proteolysis-targeting chimera (PROTAC) technology provides powerful tools to degrade these undruggable targets and has become a promising approach for drug discovery.

However, the PROTAC technology has some limitations, and emerging new degrader technologies may greatly broaden the spectrum of targets that could be selectively degraded by harnessing a second major degradation pathway in cells. We review key emerging technologies that exploit the lysosomal degradation pathway and discuss their potential applications and limitations.

SKT (KIAA1217) Antibody
abx234542-100ug	Abbexa	100 ug	EUR 509

Mouse SKT shRNA Plasmid
20-abx980555	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Mouse pre-microRNA Expression Construct mir-219-1
MMIR-219-1-PA-1	SBI	Bacterial Streak	EUR 684

Mouse pre-microRNA Expression Construct mir-219-2
MMIR-219-2-PA-1	SBI	Bacterial Streak	EUR 684

CTLA 4 Recombinant Protein
96-219	ProSci	0.2 mg	EUR 401
Description: CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Mouse Sickle tail protein (SKT) ELISA Kit
abx389166-96tests	Abbexa	96 tests	EUR 911

Mouse Sickle tail protein, Skt ELISA KIT
ELI-29595m	Lifescience Market	96 Tests	EUR 865

Human Sickle tail protein homolog, SKT ELISA KIT
ELI-18163h	Lifescience Market	96 Tests	EUR 824

hCRP FRET 96
CH1021-96	Mediomics	1 Kit	EUR 455

hCRP TRF 96
CHTR1021-96	Mediomics	1 Kit	EUR 482

hInsulin FRET 96
IH1017-96	Mediomics	1 Kit	EUR 455

hInsulin TRF 96
IHTR1017-96	Mediomics	1 Kit	EUR 482

hAlbumin FRET 96
AH1005-96	Mediomics	1 Kit	EUR 455

hAlbumin TRF 96
AHTR1005-96	Mediomics	1 Kit	EUR 482

mIgG TRF 96
MIGTR1020-96	Mediomics	1 Kit	EUR 482

rIgG FRET 96
RI1024-96	Mediomics	1 Kit	EUR 455

ATF4 (Ab-219) Antibody
CSB-PA123639-	Cusabio		EUR 335
Description: A polyclonal antibody against ATF4 (Ab-219). Recognizes ATF4 (Ab-219) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

ATF4 (Ab-219) Antibody
CSB-PA123639-100ul	Cusabio	100ul	EUR 316
Description: A polyclonal antibody against ATF4 (Ab-219). Recognizes ATF4 (Ab-219) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

Influenza HA (210 - 219)
5-01388	CHI Scientific	4 x 5mg	Ask for price

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit
EF014796	Lifescience Market	96 Tests	EUR 689

HSP70 ELISA Kit
SKT-105-96	Cusabio	1 plate of 96 wells	EUR 581
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit
SKT-106-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit
SKT-107-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)
SKT-108-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit
SKT-109-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit
SKT-110-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit
SKT-111-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit
SKT-113-96	Stressmarq	1 plate of 96 wells	EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit
SKT-123-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)
SKT-124-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit
SKT-126-96	Stressmarq	1 plate of 96 wells	EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit
SKT-137-96	Stressmarq	1 plate of 96 wells	EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit
SKT-140-96	Stressmarq	1 plate of 96 wells	EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit
SKT-201-96	Stressmarq	1 plate of 96 wells	EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit
SKT-202-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit
SKT-203-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit
SKT-204-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit
SKT-205-96	Stressmarq	1 plate of 96 wells	EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit
SKT-206-96	Stressmarq	1 plate of 96 wells	EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit
SKT-207-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)
SKT-208-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP EIA Kit
SKT-209-96	Stressmarq	1 plate of 96 wells	EUR 454
Description: Direct EIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP CLIA Kit (High-Sensitivity)
SKT-210-96	Stressmarq	1 plate of 96 wells	EUR 520
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit
SKT-211-96	Stressmarq	1 plate of 96 wells	EUR 474
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Nitric Oxide Detection Kit
SKT-212-96	Stressmarq	2 plates of 96 wells	EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Retinol Binding Protein Urinary EIA Kit
SKT-218-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey

Polyclonal RAB37 Antibody (aa170-219)
AMM07470G	Leading Biology	0.05ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RAB37 (aa170-219). This antibody is tested and proven to work in the following applications:

ATF-4 (Ab-219) Antibody
33307-100ul	SAB	100ul	EUR 252

ATF-4 (Ab-219) Antibody
33307-50ul	SAB	50ul	EUR 187

Influenza HA (210 219) Peptide
20-abx266173	Abbexa	EUR 439.00 EUR 718.00 EUR 328.00	10 mg 25 mg 5 mg

rno-miR-219-5p Primers
MP-r00147	ABM	150 ul / 10 uM	EUR 176

hsa-miR-219-5p Primers
MPH01276	ABM	150 ul / 10 uM	EUR 121

mmu-miR-219-3p Primers
MPM00250	ABM	150 ul / 10 uM	EUR 121

mmu-miR-219-5p Primers
MPM00251	ABM	150 ul / 10 uM	EUR 121

Tissue Culture Plate, 96 Well
TCP20-96	Bio Basic	1 UNIT	EUR 53.48

Aligned Nanofibers 96 Well Plate
3D00012-96	Neuromics	700 nm-PCLs	EUR 110

Bridge-It cAMP-PDE 96
PD1016-96	Mediomics	1 Kit	EUR 455

Recombinant Human CD59 Protein-10His tag
CTP-219	Creative Biolabs	100ug	Ask for price
Description: A 10.3 kDa recombinant human CD59 protein with a C-terminal 10-His tag expressed in the mouse myeloma cell line, NS0.

Recombinant P. falciparum MSP-1 [His]
DAGA-219	Creative Diagnostics	1 mg	EUR 441

pSMPUW-IRES-Blasticidin Lentiviral Expression Vector
VPK-219	Cell Biolabs	10 µg	EUR 624
Description: Clone your gene of interest into this Lentiviral Expression Vector, then co-transfect along with lentiviral packaging vectors into a packaging cell line such as 293LTV. This expression vector is compatible with any 2nd or 3rd generation lentiviral packaging system, but due to its design it is best matched with our ViraSafe packaging vectors to produce the highest viral titer.

XMIRXpress lentivector miRNA-219a-5p with Xmotif
XMIRXP-219	SBI	10 ug	EUR 677

IL-8 / CXCL8 Recombinant Protein
11-219	ProSci	0.1 mg	EUR 595.25
Description: Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

SARS Coronavirus spike (HSZ-Cc) Recombinant Protein
20-219	ProSci	0.1 mg	EUR 605.75
Description: SARS Coronavirus spike (HSZ-Cc) Recombinant Protein

Annexin V ATTO 488 Recombinant Protein
90-219	ProSci	100 tests	EUR 364.25
Description: Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e. g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.

Neurocalcin-delta Recombinant Protein
91-219	ProSci	0.05 mg	EUR 710.75
Description: Neurocalcin-delta (NCALD) is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family. It expressed in mammalian brains. NCALD contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein possesses a Ca2+ /myristoyl switch. It is cytosolic at resting calcium levels. However, elevated intracellular calcium levels induce a conformational change which exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. NCALD protein is thought to be a regulator of G protein-coupled receptor signal transduction.

IL-1 beta Recombinant Protein
92-219	ProSci	0.05 mg	EUR 542.75
Description: IL1B belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and is reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Mouse Lymphocyte Antigen 96 ELISA kit
E03L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Lymphocyte Antigen 96 ELISA kit
E02L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Lymphocyte Antigen 96 ELISA kit
E01L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Lymphocyte Antigen 96 ELISA kit
E07L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Lymphocyte Antigen 96 ELISA kit
E06L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Lymphocyte Antigen 96 ELISA kit
E04L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Lymphocyte Antigen 96 ELISA kit
E08L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Lymphocyte Antigen 96 ELISA kit
E09L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

96 WELL CLEAR PCR MICROPLATE
PCR-96-C	CORNING	10/pk	EUR 145
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

Ring Finger Protein 219 (RNF219) Antibody
20-abx338409	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Ring Finger Protein 219 (RNF219) Antibody
20-abx006113	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Zinc Finger Protein 219 (ZNF219) Antibody
abx031235-400ul	Abbexa	400 ul	EUR 523

Zinc Finger Protein 219 (ZNF219) Antibody
abx031235-80l	Abbexa	80 µl	EUR 286

Zinc Finger Protein 219 (ZNF219) Antibody
abx031236-400ul	Abbexa	400 ul	EUR 523

Zinc Finger Protein 219 (ZNF219) Antibody
abx031236-80l	Abbexa	80 µl	EUR 286

Ring Finger Protein 219 (RNF219) Antibody
abx029648-400ul	Abbexa	400 ul	EUR 523

Ring Finger Protein 219 (RNF219) Antibody
abx029648-80l	Abbexa	80 µl	EUR 286

Ring Finger Protein 219 (RNF219) Antibody
abx237352-100ug	Abbexa	100 ug	EUR 551

hsa-miR-219-5p miRNA Inhibitor
MIH01575	ABM	2 x 5.0 nmol	EUR 176

mmu-miR-219-3p miRNA Inhibitor
MIM01527	ABM	2 x 5.0 nmol	EUR 176

mmu-miR-219-5p miRNA Inhibitor
MIM01528	ABM	2 x 5.0 nmol	EUR 176

rno??miR-219-5p miRNA Inhibitor
MIR01323	ABM	2 x 5.0 nmol	EUR 176

mmu-miR-219-3p miRNA Antagomir
MNM01527	ABM	2 x 5.0 nmol	EUR 329

mmu-miR-219-5p miRNA Antagomir
MNM01528	ABM	2 x 5.0 nmol	EUR 329

rno??miR-219-5p miRNA Antagomir
MNR01323	ABM	2 x 5.0 nmol	EUR 329

hsa-miR-219-1-3p Primers
MPH01274	ABM	150 ul / 10 uM	EUR 121

hsa-miR-219-2-3p Primers
MPH01275	ABM	150 ul / 10 uM	EUR 121

hsa-miR-219-5p miRNA Antagomir
MNH01575	ABM	2 x 5.0 nmol	EUR 329

Guinea pig Lymphocyte Antigen 96 ELISA kit
E05L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

96 WELL PCR SEGMENTED PLATE
PCR-96-SG-C	CORNING	10/pk	EUR 145
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen