CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-γ Producing Innate Lymphoid CelIs and Protects From Experimental Colitis

CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-γ Producing Innate Lymphoid CelIs and Protects From Experimental Colitis

A various spectrum of immune cells populates the intestinal mucosa reflecting the continual stimulation by luminal antigens. In lesions of sufferers with inflammatory bowel illness, an aberrant inflammatory course of is characterised by a really outstanding infiltrate of activated immune cells producing cytokines and chemokines. These mediators perpetuate intestinal irritation or might contribute to mucosal …

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