Integrated transcriptomics and metabolomics analyses reveal benzo[a]pyrene enhances the toxicity of mercury to the Manila clam, Ruditapes philippinarum

Integrated transcriptomics and metabolomics analyses reveal benzo[a]pyrene enhances the toxicity of mercury to the Manila clam, Ruditapes philippinarum

Mercury (Hg<sup>2+</sup>) and benzo[a]pyrene (BaP) are ubiquitous and persistent pollution with a number of toxicities in bivalve molluscs. Here, the toxicological responses in the gills of Manila clams, Ruditapes philippinarum, to Hg<sup>2+</sup> (10 μg L<sup>-1</sup>), BaP (<em>3</em> μg L<sup>-1</sup>), and their combination have been analysed utilizing transcriptomics and metabolomics approaches. Comparisons of the transcriptomes and …

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